LINCS Cell Line Data Integrated into ChEMBL

Posted on: February 20th, 2015 by Sherry Jenkins No Comments

CHEMBL now provides CHEMBL IDs for all cell lines stored in their database and also cross references to the LINCS project.


Administrative Supplements to Extend the Scope and Reach of LINCS Datasets

Posted on: February 20th, 2015 by Sherry Jenkins No Comments

This notice (NOT-RM-15-102) announces an opportunity to request administrative supplements to existing NIH research grants, to support generation of new data that will also advance the goals of the LINCS program.

Call for External Collaborations with the LINCS-DCIC

Posted on: January 24th, 2015 by Avi Maayan No Comments

The LINCS DCIC announces a call for applications for the next round of external data science research projects. The call is for two year projects that would leverage LINCS generated data through application of novel computational methods. For more information, please visit:

LINCS Data Science Research (DSR) Webinar (12-16-2014)

Posted on: December 16th, 2014 by Caty Chung No Comments

Tuesday (12-16-2014) at 3:00PM EST
“Large-scale integration of small molecule-induced responses in diverse LINCS datasets ”
Dr Dusica Vidovic
University of Miami DCIC

Cloud based access to datasets released

Posted on: May 21st, 2014 by Documentation No Comments

Broad Institute LINCS U54 center releases cloud-based access to LINCS datasets and WebApps. More details at

LINCS Data Working Group publishes on metadata standards

Posted on: February 11th, 2014 by Documentation No Comments

Vempati et al., Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS) J Biomol Screen June 2014 19: 803-816

Applicant Information Webinar for RFA-HG-14-001 BD2K-LINCS-Perturbation Data Coordination and Integration Center (DCIC) (U54)

Posted on: December 19th, 2013 by Documentation No Comments


January 13, 2014, 1:00pm – 2:30pm ET
Chairs: Dr. Jennie Larkin, Dr. Ajay Pillai


Reference for RFA-HG-14-001

An Applicant Information Webinar will be held on Monday, January 13, 2014, from 1:00 – 2:30 pm ET, to provide information about the Library of Integrated Network-based Cellular Signatures (LINCS) FOA to prospective applicants. This FOA seeks applications to develop a data coordination and integration center (DCIC) that will address the opportunities and challenges provided by two major NIH efforts: Big Data to Knowledge (BD2K) and the Library of Integrated Network-Based Cellular Signatures (LINCS). The NIH expects that this BD2K-LINCS DCIC will focus on perturbagen-response data and signatures while ensuring that the resulting resources are effectively utilized by the community by addressing challenges related to biomedical Big Data. A successful DCIC will ensure consistent annotation of data and tools generated within the LINCS program; incorporate (without replicating databases) relevant non-LINCS perturbation data into the LINCS resource; support integration of relevant data, signatures, and tools to allow for seamless exploration of the (LINCS) program’s output by a broad range of biomedical researchers; support linkages to outside knowledge bases, data portals, and resources; support training in perturbation-data science skills; build innovative access and query tools to disparate databases hosting multiple data types; and disseminate the resulting tools and resources to the broad range of biomedical researchers. Related FOAs of relevance to the DCIC include RFA-RM-13-013 soliciting applications for LINCS data and signature generation and RFA-HG-13-009 soliciting applications for BD2K Centers of Excellence.

Information on how to participate in the webinar:

  • Registration: None
  • Audio: Dial: 1-800-779-8174
  • Participant Code: 38-60-157
  • URL:
  • Contact:

    Slides with background information that will be displayed during the webinar will be available here shortly before the webinar begins. A document with the questions and responses addressed during the webinar, and an audio recording of the webinar will also be made available on this website.

First Public LINCS Symposium held

Posted on: November 18th, 2013 by Documentation No Comments

The first public LINCS symposium was held at the Broad Institute in Cambridge MA, featuring podium presentations by invited speakers and workshops conducted by staff from the LINCS U54 and U01 centers.
View an archive of material presented.

Public Conference on LINCS to be Held at the Broad Institute in November 2013

Posted on: September 10th, 2013 by Documentation

November 18:
Broad Institute. 7 Cambridge Center, Cambridge, MA

November 19:
Joseph B Martin Conference Center. 77 Avenue Louis Pasteur,
Harvard University Longwood Campus, Boston, MA.

See below for full agenda.

Over the past 3 years, the LINCS consortium has generated a range of novel datasets and analytical tools with the goal of enabling the biomedical research community with new approaches to link disease biology, genome biology and chemical biology. Members of the LINCS consortium have already begun using these datasets towards questions of interest to their laboratories and those of close collaborators. A few of these efforts have been published and several more are nearing completion.

To facilitate community uptake, we are organizing the first public conference on LINCS to be held at the Broad Institute in November 2013. The conference will feature a number of workshops (hosted by LINCS centers) as well as presentations by current and anticipated users of LINCS so as to create a robust discussion on how the data can be used for biological discovery. 

The conference agenda will include:

  • Workshops to educate novice and advanced users on using LINCS resources 
  • Invited presentations on current and anticipated uses of LINCS data
  • Sessions to gather feedback from attendees on future directions of LINCS

Full agenda and registration. For questions please email

Webinar for RFA-RM-13-013 LINCS: Perturbation-Induced Data and Signature Generation Centers (U54)

Posted on: September 9th, 2013 by Documentation

An applicant information webinar for RFA-RM-13-013 Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54) was held on Friday, September 6, 20e?13. Listen to the audio from the webinar here. View the slides displayed during the webinar here.

A text file of questions and answers from the webinar is here. In some cases, these answers are more comprehensive than what you may find in the audio transcript.