Metadata and standards
The LINCS Data Working Group (DWG) is developing standards for the metadata describing LINCS reagents, assays and experiments. Annotations for the perturbagens (small molecules, siRNA, growth factors and other ligands), cells, and some elements of experimental metadata should be common between all LINCS Centers. This will facilitate development of data analysis, formatting, and visualization strategies by LINCS investigators, and also the development of databases and data repositories in which to store and share LINCS data.
Standardized LINCS Small Molecules IDs (Released 11/14/2012)
Current releases for LINCS Metadata Standards for reagents used in LINCS experiments are downloadable below. These documents annotate reagents outside the context of the experiments in which they will be used. For example, the small molecules standards do not include solvent information as that is usually specific to the experimental context in which the reagent is used. Please note that the ‘Unique ID’ field in these documents is used by the LINCS DWG to track fields and is not meant for any other purpose.
Cell Lines (Released 4-11-12)
Primary cells (Released 4-11-12)
Small molecules (Released 5-4-12)
RNAi reagents (Released 7-31-12)
Protein reagents (Released 7-31-12)
Antibody reagents (Released 10-12-12)
Other reagents(Released 11-7-12)
The LINCS DWG will also develop standards to annotate the metadata that should be reported to describe LINCS assay protocols, data analysis strategies, and datasets. As much as possible we plan to make use of experimental metadata standards developed by other groups such as the ISA infrastructure project, the MIBBI efforts (e.g. MIACA, MIARE), and NCBI PubChem.