The LINCS program is implemented in two parts: pilot phase 1 (FY 2010) and the continuation of the program production phase 2. This part of the program consists primarily of LINCS Data and Signature Generation Centers. Phase 2 will also synergize with the efforts of the NIH Big Data to Knowledge (BD2K) program.
LINCS Production Phase 2
LINCS Data and Signature Generation Centers
The LINCS Data and Signature Generation Centers are six research centers. These centers are focused on high-throughput experiments that examine the changes that occur when a variety of different cell lines are exposed to perturbations.
- Harvard Medical School: HMS-LINCS
- Broad Institute: LINCS Center for Transcriptomics
- Broad Institute: LINCS Center Proteomic Characterization Center for Signaling and Epigenetics
- Oregon Health and Science University: MEP-LINCS
- University of California, Irvine: NeuroLINCS
- Icahn School of Medicine at Mount Sinai: Drug Toxicity Signature Generation Center
BD2K-LINCS Data Coordination and Integration Center
The Big Data to Knowledge (BD2K) Data Coordination and Integration Center (DCIC) for the Library of Integrated Network-based Signatures (LINCS) will construct a high-capacity scalable Integrated Knowledge Environment (IKE), fund several internal and external Data Science Research (DSR) projects, provide and support a Community Training and Outreach (CTO) program.
The organizational structure of the Center includes a strong Consortium Coordination and Administration (CCA) that supports and manages the Center’s goals and deliverables, and coordinates activities across the LINCS and BD2K programs.
LINCS Pilot Phase 1 (fiscal year completion 2013)
The LINCS Pilot Phase 1 was composed of 10 centers: two data production/analysis centers, that generate data for the LINCS matrix, four centers dedicated to developing technology to complement and facilitate the collection of cellular signatures, and four centers that are developing computational tools for analyzing the data produced by the data production centers. In addition, two external supplements, as well as a number of internal collaborations, support and augment the work done by the LINCS centers.